Gabapentin
Limited reports on the efficacy in PFIC but has been trialed in refractory (= hard to treat) itch
This is primarily an anti-seizure medication. A secondary effect of Gabapentin seems to be to inhibit a peptide that is involved in mediating itch. has been used when itch is thought to have a neuropathic or central nervous system origin.
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Of the six main areas mainly affected by PFIC, patients & the community have identified the areas impacted by this medication.
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